Bertie Göttgens

英国剑桥大学

Bertie Gottgens is the Director of the Wellcome – MRC Cambridge Stem Cell Institute and Professor of Molecular Haematology at the University of Cambridge. He obtained his undergraduate training in biochemistry at the University of Tübingen, and DPhil at the University of Oxford.

Gottgens’ major research contributions have all been focussed on a central paradigm of stem cell biology, which is the question of how multipotent stem cells execute cell fate choices. Careful control of cellular decision making is vital to build and maintain all our organs, as well as mediating organ repair and regeneration. However, how stem cells decide whether to selfrenew or generate mature progeny remains poorly defined. Gottgens’ early work delivered the first molecular understanding of key regulatory processes that define blood stem cell identity. Having deciphered the blood stem cell regulatory code, he then exploited this knowledge to generate computer models that faithfully capture the behaviour of normal blood stem cells, and model dysregulation of stem cell function in leukaemia. During the past 5 years, he has led the field in using new single cell profiling technologies, and expanded his scope beyond blood development, by charting cellular diversification in mammalian embryos, all the way from pluripotent stem cells to the progenitors of all major organs.

His achievements have gained broad recognition (Member of the European Molecular Biology Organisation, Fellow of the Academy of Medical Research, President of the International Society for Experimental Hematology). Moreover, he is associate editor of the leading journal BLOOD, MRC board member, and has an exemplary record in training the next generation of scientists in his interdisciplinary approach to biomedical research.

His achievements have gained broad recognition (Member of the European Molecular Biology Organisation, Fellow of the Academy of Medical Research, President of the International Society for Experimental Hematology). Moreover, he is associate editor of the leading journal BLOOD, MRC board member, and has an exemplary record in training the next generation of scientists in his interdisciplinary approach to biomedical research.