Dr. Tianpeng Gu received his Ph.D. degree from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (SIBCB, CAS) in 2012. He recently joined Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences as an assistant professor after years of postdoctoral training in SIBCB and Baylor College of Medicine (BCM). His research is mainly focused on epigenetic mechanisms, particularly DNA methylation dynamics regulated by DNA methyltransferases (DNMTs) and TET dioxygenases in stem cells and development: 1) revealed an in vivo biological function of the disordered N-terminal domain of DNMT3A1 in mouse postnatal development; 2) demonstrated a complementary and cooperative regulation of epigenetic landscapes by DNMT3A and TET1 in mouse embryonic stem cells; 3) uncovered an essential role of TET3-mediated DNA oxidation and demethylation in epigenetic reprogramming in the early embryos. Currently, Dr. Gu continues his efforts to understand the interplay between DNA methylation and other epigenetic mechanisms and investigate the pathogenesis of patient-specific mutations of epigenetic regulators to guide targeted therapy for human diseases including hematologic malignancies.