Dachuan received his BS degree at Nanjing University in China in 2010, and PhD degree at Albert Einstein College of Medicine in the United States in 2016. He conducted his PhD and postdoctoral studies under the supervision of Dr. Paul Frenette, a leading scientist in the field of hematology who passed away too early in 2021. He received the Chinese National Natural Science Fund for Excellent Young Scientists (Overseas), and joined Shanghai Jiao Tong University School of Medicine as a Principal Investigator in 2022.

Dachuan focuses on the cellular and molecular regulatory network of hematopoietic stem cells (HSCs) and innate immune cells, with particular interests on the roles of gut microbiota and peripheral nervous system (PNS). His previous studies have found that the microbiota plays an important role in regulating neutrophil aging and inflammatory disease progression (Nature 2015), and in regulating HSC fate decisions under stress by modulating local iron recycle and supply via macrophages (Cell Stem Cell 2022). In addition, he collaborated in multiple studies showing key roles of the PNS in regulating HSC mobilization and the microenvironment. These studies have been published in high-impact journals including Nature, Cell Stem Cell, Blood etc. His ongoing studies aim to further dissect the interactions between the microbiota, PNS and the hematopoietic system, and to develop microbiota- or neuron-based novel therapeutic strategies for blood disorders.